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KMID : 0352720170410030373
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Journal of Ginseng Research
2017 Volume.41 No. 3 p.373 ~ p.378
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Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
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Liu Juan
Xu Yang Rong
Yang Jing Jing
Wang Wen Zhi
Zhang Jian Qiang
Zhang Ren Mei
Meng Qing Guo
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Abstract
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Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.
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KEYWORD
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biological activity, discovery, metabolism, ocotillol-type saponin, semisynthesis
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